THE GREY

Lilly Says Its Pill Beats Novo’s Pill. There’s Just One Catch: They Never Faced Each Other.

The obesity market has become so competitive that companies no longer wait for their drugs to meet in the same clinical trial before declaring a winner. Eli Lilly said Monday that...
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THE GREY
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THE GREY

WuXi AppTec Is Off the Pentagon’s Military List. The BIOSECURE Clock Is Still Running

WuXi AppTec, one of the world's largest contract drug developers and manufacturers and an important producer of peptides, is off the Pentagon's list of Chinese military companies. The U.S....
THE GREY

The FDA Reportedly Shelved the Fast Lane That Sped Up Wegovy and Foundayo

The fastest lane at the Food and Drug Administration appears to be closing without a public announcement. The Commissioner's National Priority Voucher program, a pilot that promised drug reviews...
THE SCIENCE
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THE SCIENCE

Explainer: What the Evidence Really Says About GLP-1 Drugs in Type 1 Diabetes

Searches for "Mounjaro type 1 diabetes" keep returning a question the clinical record has not fully answered. Type 1 diabetes is an autoimmune disease in which the body's insulin-producing cells are...
THE SCIENCE

Corn Smut Hides a Peptide Inside a Protein. The Plant’s Own Enzymes Hand It Over

Corn smut is the fungus that turns maize kernels into grey, swollen galls. In Mexico, young galls are harvested as huitlacoche and sold as...
THE SCIENCE

Trevogrumab Preserved Lean Mass on Semaglutide. The Combination Arm Is the Warning

Trevogrumab, an experimental antibody from Regeneron, substantially reduced the lean tissue people lost while taking semaglutide, according to the full results of the COURAGE...

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PEPTIDES
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PEPTIDES

Blackstone Will Pay Up to $1.5 Billion of Berobenatide’s Bills. Pfizer Keeps the Whole Drug

Pfizer has found someone else to help pay for its biggest obesity bet. On November 11, Pfizer and Blackstone Life Sciences said funds managed...
PEPTIDES

Ozempic Starts in Yeast. Zepbound Is Built by Chemists. Inside the Two Ways GLP-1 Peptides Get Made

Every GLP-1 injection starts as a manufacturing decision. A peptide drug is a chain of amino acids, and there are two major ways to...
REAL STORIES
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REAL STORIES

Elizabeth Hughes Weighed 45 Pounds When She Got Insulin. She Spent 58 Years Keeping It Secret

Historical profile. When Elizabeth Hughes arrived in Toronto in August 1922, she weighed 45 pounds. She was 14, days short of her fifteenth birthday,...
REAL STORIES

Sadaf Farooqi Treated One Girl Who Couldn’t Make Leptin. It Changed How Medicine Sees Hunger

Historical profile. In a report published in 1999, Cambridge doctors described a 9-year-old girl who weighed 94.4 kilograms, about 208 pounds. She had a...